Are you a high school student passionate about biology, biotechnology, or neuroscience? Whether you're captivated by the inner workings of a cell, dream of solving global health issues, or love the thrill of scientific discovery, biology competitions offer a fantastic way to deepen your knowledge, build your resume, and challenge yourself on a national stage.
In this post, we’ll walk through some of the top biology competitions for high school students in the United States — from research-based challenges to prestigious Olympiads — and help you find the ones that align with your interests and goals.
1. USA Biology Olympiad (USABO)
Best for: Students strong in theoretical and conceptual biology
What it is: The most prestigious biology exam-based competition in the U.S.
Why it matters: Top scorers are invited to a training camp, and the top 4 represent the U.S. at the International Biology Olympiad.
Website: usabo-trc.org
2. Regeneron Science Talent Search (STS)
Best for: Seniors with original research in biology or life sciences
What it is: Often called the “Junior Nobel Prize,” this is the top research competition for U.S. high school seniors.
Why it matters: Finalists receive national recognition, scholarships, and exposure to elite researchers.
Website: societyforscience.org/sts
3. Regeneron International Science and Engineering Fair (ISEF)
Best for: Students with strong research projects in biology
What it is: The world’s largest high school science fair, where students compete in categories like microbiology, cellular biology, and environmental science.
Why it matters: Thousands in prizes and global recognition; projects can lead to patents and publications.
Website: societyforscience.org/isef
4. U.S. Brain Bee
Best for: Students interested in neuroscience
What it is: A neuroscience competition focused on the structure and function of the brain.
Why it matters: Regional winners compete nationally, and top students go to the International Brain Bee.
Website: thebrainbee.org
5. BioGENEius Challenge
Best for: Students interested in biotechnology and real-world applications of biology
What it is: A research competition focused on biotech innovation, including environmental, medical, and agricultural applications.
Why it matters: Finalists present at the BIO International Convention alongside professionals.
Website: biotechinstitute.org
6. Junior Science and Humanities Symposium (JSHS)
Best for: Students who enjoy presenting biology research
What it is: Sponsored by the Department of Defense, JSHS emphasizes student-led research with a strong presentation component.
Why it matters: Winners receive scholarships and attend a national symposium.
Website: jshs.org
7. ASM Agar Art Contest (High School Division)
Best for: Creative students interested in microbiology
What it is: A unique competition where students create art using living microbes grown on agar plates.
Why it matters: Merges art and science while promoting microbiology education.
Website: asm.org
8. Amgen Biotech Experience Essay Contest
Best for: Students in Amgen-affiliated programs
What it is: Essay competition reflecting on students’ experience in biotechnology labs.
Why it matters: Encourages students to explore the ethical, social, and personal dimensions of biotech.
Website: amgenbiotechexperience.com
9. ExploraVision
Best for: Students interested in futuristic solutions using biology
What it is: A team competition where students propose future technologies based on current science.
Why it matters: National recognition for creative science thinking.
Website: exploravision.org
Why Compete?
Final Thoughts
Whether you're aiming to compete in the USABO or present a biotech invention at ISEF, there's a biology competition out there for every kind of learner. Start early, follow your curiosity, and don't be afraid to experiment. These experiences can ignite lifelong passions and open doors to future academic and professional opportunities.